Tc1 mice present with macrocytic anemia throughout life. (A) Graphs of mean (± SEM) red blood cell (RBC), white blood cell (WBC), and platelet counts and mean corpuscular volume (MCV) of neonate (< 1 day old) Tc1 and wild-type (Wt) mice (n = 6). (B) Graphs show mean (± SEM) RBC, WBC, and platelet counts and MCV as a function of age of Tc1 and wild-type mice (n = 15). Tc1 mice show decreased RBC counts from 8 to 52 weeks of age and increased MCV from 4 to 52 weeks of age (P < .05). (C) Low-power (left) and high-power (right) views of Wright-Giemsa–stained blood smears from Tc1 mice aged 64 weeks showing clouds of platelets.