Clinical features associated with LEF1 inactivation. (A-B) Kaplan-Meier analysis of event-free survival rates shows that LEF1 status is not a significant predictor of response to initial therapy; however, there was a trend toward improved overall survival in patients with LEF1-inactivated T-ALL, suggesting that this molecular subtype of the disease may be more responsive to salvage therapy for relapsed T-ALL. (C) LEF1 inactivation is associated with a younger age at the time of T-ALL diagnosis. P value was calculated by the Wilcoxon rank-sum test.