Treatment paradigm for SC-EPOCH-RR. Thirty-three patients with DLBCL received 2 cycles of EPOCH-RR after which time CT and FDG-PET scans were performed. Response was based on serial CT body and FDG-PET scans, beginning at cycle 3 day 1 and performed after each cycle thereafter until treatment completion. Patients who had “negative” studies, as defined in “Evaluation and treatment,” received 1 additional cycle (minimum of 3) of therapy. Patients who had a “positive” CT and/or FDG-PET study received additional cycles until they were negative, for a maximum of 6 cycles. Two patients with progressive disease on treatment did not complete their initial therapy.