The “budding” of platelets from proplatelets, and then from mature platelets, during thrombopoiesis. Megakaryocytes in the bone marrow extend cytoplasmic projections (proplatelets) between endothelial cells into the sinusoidal lumen. The proplatelets pinch off their tips to form platelets. In a similar process, a circulating platelet is capable of extending a thin cytoplasmic projection and transferring some of its metabolic, granular, and organelle contents into an attached cell body to construct a duplicated new platelet. The dark circles in the proplatelets and platelets represent microtubules. (For an example of the platelet replication process, see Figure 1A in the article by Schwertz et al on page 3801.)

The “budding” of platelets from proplatelets, and then from mature platelets, during thrombopoiesis. Megakaryocytes in the bone marrow extend cytoplasmic projections (proplatelets) between endothelial cells into the sinusoidal lumen. The proplatelets pinch off their tips to form platelets. In a similar process, a circulating platelet is capable of extending a thin cytoplasmic projection and transferring some of its metabolic, granular, and organelle contents into an attached cell body to construct a duplicated new platelet. The dark circles in the proplatelets and platelets represent microtubules. (For an example of the platelet replication process, see Figure 1A in the article by Schwertz et al on page 3801.)

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