Analysis of MALT lymphoma breakpoints. (Top) Frequency of MALT1 cluster region breakpoints at various distance intervals from CpG. Proportions of MALT1 cluster region breakpoints at distances of 0 bp, 1 to 2 bp, 3 to 4 bp, 5 to 8 bp, and > 8 bp from CpG are graphed. The distribution for actual lymphoma or leukemia breakpoints is in dark gray, while that for a random distribution between the farthest breakpoints is in light gray. If the dark gray and light gray bars parallel one another, then the patient breakpoints appear random in their distribution relative to the specified motif. However, when they follow opposite trends, that is, the light gray bars rise with increasing distance from the specified motif while the dark gray bars fall, then the breakage process appears to concentrate around the motif. (Bottom) Breakpoint distribution on the MALT1 cluster region. MALT lymphoma breakpoints in the MALT1 cluster region identified by Murga Penas et al are plotted. Each breakpoint is represented as a triangle adjoining the breakpoint site, with the top strand sequences running telomeric to centromeric, der(14) breakpoints above, and der(18) breakpoints below. CpGs are highlighted in black, and the lone CAC(A) highlighted in gray.