Figure 1
ADAP−/− mice exhibit abnormal thrombus formation in vivo. (A) Representative carotid artery blood flow tracings from ADAP+/+ and ADAP−/− mice. A filter paper impregnated with 3.75% FeCl3 was applied for 3 minutes (▼), and blood flow was monitored for an additional 25 minutes. (B) The average time to first occlusion was determined for each mouse, and results are shown as the average ± SEM of at least 7 mice per strain. *P < .01. (C) Hematoxylin and eosin–stained sections through the carotid artery excised 30 minutes after application of FeCl3 (ADAP+/+, left; ADAP−/−, middle) or buffer (ADAP+/+, right).

ADAP−/− mice exhibit abnormal thrombus formation in vivo. (A) Representative carotid artery blood flow tracings from ADAP+/+ and ADAP−/− mice. A filter paper impregnated with 3.75% FeCl3 was applied for 3 minutes (▼), and blood flow was monitored for an additional 25 minutes. (B) The average time to first occlusion was determined for each mouse, and results are shown as the average ± SEM of at least 7 mice per strain. *P < .01. (C) Hematoxylin and eosin–stained sections through the carotid artery excised 30 minutes after application of FeCl3 (ADAP+/+, left; ADAP−/−, middle) or buffer (ADAP+/+, right).

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