Cumulative incidence of acute GVHD grades II through IV after HSCT according to the discrepancy of HPSE gene SNPs rs4693608 and rs4364254 combinations between recipient and donor. The D1 group contains HR-MR and HR-LR recipient-donor genotype combination pairs; the D2 group contains MR-MR, MR-HR, MR-LR, and HR-HR recipient-donor pairs; and the D3 group contains LR-LR, LR-MR, and LR-HR recipient-donor pairs. The incidence was higher in group D1 compared with the D2 and D3 groups (P < .001).