Lymphomagenesis in HTLV-1 HU-NOD/SCID mice. Representative histologic analysis of HTLV-1-HU-NOD/SCID mice and mock mice killed 14 to 16 weeks after reconstitution. Development of lymphomas localized to the mesenteric (MLN) and lymph nodes surrounding the pancreas (PLN; red arrows) and spleen (A-B,D) in HTLV-1-HU-NOD/SCID mice in comparison with mock-infected HU-NOD/SCID mice (C,E). H&E staining of MLN (F), pancreatic lymph nodes (G), and infiltrating lymphocytes in spleen (I) of HTLV-1-HU-NOD/SCID mice in contrast to lymph nodes (H) and spleen (J) of mock-infected HU-NOD/SCID mice. H&E staining shows diffuse large scale lymphomas in the kidney, pancreas, liver, and lungs (K,M,O,Q) of HTLV-1-HU-NOD/SCID mice in comparison with kidney, pancreas, liver, and lungs (L,N,P,R) of mock-infected HU-NOD/SCID mice. Insets (K,M,O,Q) show immunohistochemical analysis for human CD45.