Thrombin generation in human and mouse PRP. TF-triggered thrombin generation was measured in PRP. Human PRP was preincubated with (A) a PN-1–blocking IgG (150 μg/mL) or (B) a PAI-1–blocking IgG (150 μg/mL). Mouse PRP was from (C) PN-1–deficient mice or (D) PAI-1–deficient mice on thrombin. Results are from one experiment performed in triplicate, representative of at least 3 independent experiments.