Comparison of the HCDR3 sequences of CLL and normal B cells in the 51p1-IGHJ6–derived subset 5. Amino acid sequences of the HCDR3 of each normal sequence aligned to the closest CLL HCDR3 are represented. Dashes indicate homology to the germline IGHV1-69, IGHD3-10 in reading frame (RF) 3, and IGHJ6 genes at the top of the figure. Identical N1 and N2 amino acids between different sequences are highlighted in shades of gray.