Associations and LD structure for VAV3. (A) Association of the 17 SNPs in the VAV3 locus on chromosome 1p13.3 for each of the 4 functional platelet responses (reading from the top; PA, PC, FA, and FC). Arrow indicates the SNP with the highest association in the PA response. LD structure is based on HapMap data (as described for Figure 4), and chromosomal position (in Mb) based on NCBI build 36 coordinates, showing Ensembl (version 49) gene structure. (B) Expression of VAV3 protein measured by flow cytometry in unstimulated platelets of subjects homozygous (GG) for the major allele of rs17229705 (solid line) or heterozygous (GA; dotted line). (C) Expression of VAV3 protein in platelets from 17 subjects who were either homozygous major (GG) or heterozygous (GA) for rs17229705.