Ship and C/ebpβ are direct targets of miR-155. (A) Spleen, immunohistochemistry, 200×. SHIP-1 is highly expressed in normal B and T lymphocytes (Olympus BX41 microscope and software; the bar represents 200 μm). (B) Malignant lymphocytes do not stain for SHIP-1 due to the loss of its expression. (C-D) Luciferase activity assay forShip-3′-UTR and C/ebpβ, wild-type and mutant, after the control (□) and miR-155 (■) transfections in 293 cells.