Schematic of Wnt5A signaling in CXC12-mediated T-cell migration. CXCL12 binds to CXCR4 and activates PKC. Both PKC activation and CXCL12/CXCR4 signaling, possibly via unknown mechanisms, can increase the transcription and translation of Wnt5A. This can act in a positive feedback loop, in which Wnt5A can then increase CXCR4 expression, resulting in increased signaling, and ultimately increased migration, perhaps via Rac, actin, and myosin, as demonstrated by Witze et al.¹²