Figure 5
Figure 5. R-sIL-7gly injection induces T-cell homing into organs. Rhesus macaques injected with R-sIL-7gly (80 μg/kg) were killed at D1 (left pictures) and compared with untreated animals (right pictures). CD3+ cells were identified by immunohistochemistry in skin (A), jejunum (B), ileum (C), colon (D), rectum (E), and lymph node (F) samples. Magnification: ×100. CD3+ T-cell quantifications, performed on 7 to 10 fields (0.09 mm2) randomly selected from 4 slides for each organ in macaques killed at H0, H24, and D7 after R-sIL-7gly injection, are shown on the right. Statistical differences between H0 and either H24 or D7 are shown on top (Mann-Whitney test).

R-sIL-7gly injection induces T-cell homing into organs. Rhesus macaques injected with R-sIL-7gly (80 μg/kg) were killed at D1 (left pictures) and compared with untreated animals (right pictures). CD3+ cells were identified by immunohistochemistry in skin (A), jejunum (B), ileum (C), colon (D), rectum (E), and lymph node (F) samples. Magnification: ×100. CD3+ T-cell quantifications, performed on 7 to 10 fields (0.09 mm2) randomly selected from 4 slides for each organ in macaques killed at H0, H24, and D7 after R-sIL-7gly injection, are shown on the right. Statistical differences between H0 and either H24 or D7 are shown on top (Mann-Whitney test).

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