Impaired platelet aggregation in RanBP10-deficient mice. Platelets from wild-type (gray curves) and RanBP10-nullizygous animals (black curves) were adjusted to 300 nL and light transmission followed by aggregometry after stimulation with collagen (5 and 20 μg/mL, top), thrombin (0.1 and 1 U/mL, middle), and 20μM ADP alone (bottom left) or together with 10μM U46619 (bottom right). Panels represent results from 2 or 3 independent experiments, depending on the agonist.