American Society of Hematology

Figure 4

$Figure 4. Effect of PAS on p53 and Noxa expression. Differential detergent fractionation was performed on CLL cells incubated for 18 hours in the presence of 100 μM ZVAD with no further addition (NA) or with 5 or 20 μM PAS. The effect of PAS on expression of p53 (A, patient AS9) and Noxa (B, patient AS25) is shown. Immunoblotting for Hsp60 and Cox IV documents successful fractionation and for actin to demonstrate equal loading. The data are typical of 29 (A) and 32 (B) experiments.$

Effect of PAS on p53 and Noxa expression. Differential detergent fractionation was performed on CLL cells incubated for 18 hours in the presence of 100 μM ZVAD with no further addition (NA) or with 5 or 20 μM PAS. The effect of PAS on expression of p53 (A, patient AS9) and Noxa (B, patient AS25) is shown. Immunoblotting for Hsp60 and Cox IV documents successful fractionation and for actin to demonstrate equal loading. The data are typical of 29 (A) and 32 (B) experiments.

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