Flowchart of the Italian cohort patients who underwent arthroplasty. The diagram on the left shows the flow chart of the data for the whole Italian arthroplasty dataset. On the left, the area inside the dotted line shows details of the subset of patients who underwent arthroplasty in 1 of the 3 main hemophilia centers; availability of the full records of the subset allowed matching with the Italian Registry of Hemophilia to perform the time-to-event analysis (see “Results”). The table at the bottom right shows details about arthroplasty distribution by joint. The corresponding rates in the Italian hemophilia population are given in the text.