Effect of ROCK and Rac1 inhibitors on the SDF1-induced adhesion. Shown is the effect of ROCK and Rac1 inhibitors on the SDF1-induced adhesion of (A) MM cell lines and (B) plasma cells from MM patient samples to fibronectin and the adhesion of MM cell lines to BMSCs (C). Both the ROCK and Rac1 inhibitors decreased the adhesion of MM cells to fibronectin and BMSCs, and no additive effect was shown for their combination. Panels A and B: Groups compared with the corresponding SDF1-treated group. Panel C: Groups compared with the control, *P < .05; #P < .01.