Effects of bortezomib on growth of neoplastic MCs. (A) HMC-1.1 cells and HMC-1.2 cells were incubated in control medium (Co) or in medium containing various concentrations of bortezomib (as indicated) at 37°C and 5% CO₂ for 48 hours. Then, ³H-thymidine uptake was determined. Results are expressed as percentage of control (Co) and show the mean ± SD of 3 independent experiments. (B-D) Primary BM MNCs obtained from 3 patients with ASM (B, no. 1; C, no. 2; D, no. 3) were incubated in control medium (Co) or in various concentrations of bortezomib at 37°C and 5% CO₂ for 48 hours before ³H-thymidine uptake was measured. Results are expressed as percentage of control (Co) and show the mean ± SD of triplicates.