Effect of IUT on geometry and mechanical properties of femurs. (A) Geometric parameters (microCT) of femur in 2-month-old mutant untreated (Brtl, n = 8), mutant treated (Brtl + IUT, n = 12), WT untreated (n = 11), and WT treated (n = 5) mice. (B) Mechanical properties (4-points bending test) of femur in 2-month-old mutant untreated (Brtl, n = 8), mutant treated (Brtl + IUT, n = 5), WT untreated (n = 11), and WT treated (n = 5) mice. (C) Predicted Ultimate Strength and Predicted Elastic Modulus. Bars on graphs are mean ± SD. *P < .05 for Brtl + IUT vs Brtl; §P < .05 for WT + IUT vs WT, Brtl + IUT; #P < .05 for Brtl + IUT vs WT and WT + IUT; and ##P < .05 for Brtl + IUT vs WT + IUT.