BCR-ABL mutations detected before and concomitantly to the T315I mutation detection. (A) Other BCR-ABL mutations detected before the T315I mutation detection (n = 36; 16%). Two patients had 2 mutations detected in different tests (one with G250E/L273M and one with Y253H/F317L). (B) Other BCR-ABL mutations detected at the time of T315I detection (n = 52; 23%). Five patients had 2 additional mutations detected. *Solid black bars are different types of P-loop mutations.