Correlation between CCR7 expression and ability of NK cells to migrate in response to CCL19 and/or CCL21. (A-B) NK cells that had been cultured alone or cocultured with either 221 cells or mDCs were analyzed for their migratory properties in response to either CCL19 or CCL21 (A). NK cells cultured in the presence of IL-18 were also analyzed as positive control. (B) The KIR phenotype of NK cells that had been exposed to either the 221 cell line or IL-18 was evaluated before and after migration. In panel B, the values reported in the top right corner indicate the percentage of KIR⁺ NK cells. Data are representative of 8 independent experiments performed using different donors.