Most CD4^dimCD8^bright T cells are central memory T cells. (A) Cumulative data showing mean percentage of CD4⁻CD8⁺ (left) and CD4^dimCD8^bright (right) T cells, from HIV⁺ LTNP (A-B) and CMV⁺ (A,C) donors, that are central memory (CCR7⁺CD45RO⁺CD27⁺CD28⁺CD57⁻). (B-C) Representative dot plots showing raw percentages of CD4⁻CD8⁺ and CD4^dimCD8^bright T cells from HIV⁺ LTNP (B) and CMV⁺ (C) donors staining for memory-associated markers CCR7⁺CD45RO⁺ (left), then further gated CD27⁺CD28⁺ cells, and finally CD57⁺ cells. (D-G) Cumulative data (D,F) and representative flow dot plots (E,G) showing the proportion of CD4⁻CD8⁺ and CD4^dimCD8^bright T cells from HIV⁺ LTNP (D-E) and CMV⁺ (F-G) donor cells that are CFSE^dim (decreased CFSE expression and, therefore, increased proliferation) in response to no treatment (UNT), respective peptide treatment (PEP), or SEB treatment. (A,D,F) Data are based on at least 3 donors + SD. P values between groups are indicated within the figure and based on 2-tailed paired t test analysis.