Integrated view of the PMN-monocyte axis in inflammation. PMNs are rapidly recruited to the site of inflammation. Granule proteins allow for almost instant recruitment of inflammatory monocytes. Mechanisms requiring de novo synthesis of adhesion molecules and chemokines come into effect at later time points. Finally, signals generated by apoptotic PMNs attract inflammatory monocytes. Thus, the axis of PMNs and Gr1⁺ monocytes provides an acceleration of proinflammatory events.