PMN granule proteins induce monocyte adhesion and recruitment of inflammatory monocytes. (I) Granule proteins discharged from adherent PMNs anchor on endothelial proteoglycan side chains. In this location, they are recognized by monocytes rolling along the endothelium. Subsequent monocyte activation allows for their firm adhesion. (II) Granule proteins activate endothelial cells to express cell adhesion molecules such as ICAM-1 and VCAM-1 leading to enhanced monocyte adhesion. (III) Azuorcidin, LL-37, and cathepsin G released from emigrated PMNs induce extravasation of inflammatory monocytes by use of formyl peptide receptors.