Expression of Cbl mutants led to a lethal mastocytosis and myeloproliferative disease in a murine bone marrow transplantation model. (A) Kaplan-Meier survival curve for recipients of bone marrow transduced with Cbl-70Z, Cbl-R420Q, or empty vector (Control). (B) Splenomegaly in mice that received transplantations of Cbl mutant-transduced bone marrow cells; empty vector (Control). (C) Analysis of mice. BM indicates bone marrow; and PB, peripheral blood. (D) Comparison of spleen weight from mice receiving bone marrow transduced with Cbl mutants. (E) Comparison of immunophenotype of peripheral blood (PB), bone marrow (BM), and spleen cells from mice receiving bone marrow transduced with Cbl mutants representing lineage-specific antigens (Kit, CD-11b, Gr-1, B220, and CD3). (D-E) Data represent the average and SD.