Supervised analysis: AML versus healthy T cells. Heatmap created using the top 50 most significantly up- and down-regulated genes for CD4 and for CD8 in the comparison of AML versus healthy cells. Up-regulated genes are in red and down-regulated, in blue. The yellow bars on the gray vertical bar highlight genes that were also found to be differentially expressed in the CLL versus healthy cell experiment. Labeled genes are those involved in T-cell activation or signaling or with actin polarization.