Relationship between decrements in the average WBC counts and the hazard ratios for time to death associated with the DARC −46C/C genotype in HIV-infected AAs. The plot represents the hazard ratios (y-axis) for rate of progression to death estimated using Cox proportional hazards modeling in subjects with average WBC counts below the indicated cutpoints (x-axis). The hazard ratios were estimated over the range of WBC counts shown on the x-axis for every 50-cell count change. The reference group is those subjects who possess DARC −46T/T or T/C (RH = 1). Inset represents data showing an interactive effect of low total WBC count on the survival advantage associated with the DARC −46C/C genotype in HIV⁺ AAs. RH indicates relative hazards (reference RH = 1 represents AAs with DARC −46T/T or T/C); CI, confidence interval; and P, significance value estimated using Cox proportional hazards modeling with indicated parameters (a, b, and c).