Clonal analysis of hematopoiesis in 3 female patients with RARS-T. The proportion of clonal granulocytes was derived from the cleavage ratio between alleles. Calculation of the proportion of granulocytes carrying JAK2 (V617F) assumes that the mutation was present at the heterozygous state, that is, the scenario compatible with the largest clone for any given percentage of mutant alleles. Should the mutation have been present at the homozygous state, the proportion of granulocytes carrying JAK2 (V617F) would be half of that shown.