Hurdles to overcome for clinical translation of hPSC-derived therapies. Although novel therapies starting from hPSCs are an enticing prospect, multiple technical, safety, and regulatory hurdles outlined in this figure and the text will need to be surmounted for successful clinical translation. It is essential that, although regulatory and other nonscientific interests should be considered and appropriately accommodated, these considerations should facilitate and not inhibit clinical translation of hPSCs as these therapies move to the clinic.