Alignment of the selected region of the GATA1 sequence for control cells and blasts cells harboring the E2Term mutation leading to a stop codon in codon 2. (Left) The star indicates the position of a homozygous replacement of the first nucleotide of codon 2 (labeled G in violet) by a T. Below, a part of the GATA1 sequence mRNA is imprinted as light green and the coding region as dark green. (Middle and right) Placental specimen with high numbers of blasts in the fetal vessels in the placental villi with massively elevated proliferation rate in the MIB1 staining, diagnostic for TMD.