ADAMTS13 regulates infarct volume after ischemic stroke in mice. Representative TTC stain of coronal brain sections of 1 mouse for each strain 22 hours after focal cerebral ischemia in WT, Adamts13^−/−, and Adamts13^−/−/VWF^−/− (top) and corresponding brain infarct volumes quantification (bottom). Increase in infarct volume in Adamts13^−/− mice, compared with WT, depended on the presence of VWF.