Level of VWF regulates infarct volume after ischemic stroke in mice. Representative TTC stain of coronal brain sections of 1 mouse for each strain 22 hours after MCAO (top) and brain infarct volumes (bottom) in WT, VWF^+/−, and VWF^−/− mice. Deficiency or heterozygosity of VWF resulted in a significant decrease in infarct volume compared with WT.