PRT stimulation of aPC generation in vitro and in vivo. (A) Generation of aPC as in Figure 1, but with increasing concentrations of PRT. Data are ± SD of 3 experiments, each performed in duplicate. *P < .01 vs no PRT. (B) Generation of aPC as in Figure 2 with TM-expressing or control K293 cells, but with increasing concentrations of PRT. Data are mean ± SD of 3 experiments, each performed in duplicate. *P < .02 vs no PRT. (C) Generation of aPC as in Figure 3 with PF4^KO mice, but with PRT or PF4 infused (n = 4 or 5 animals per arm). Data are mean ± SD. n.s. indicates not significant.