Figure 1
![Figure 1. Genetic analysis of the described patients. (A) Pedigree of the 2 families. (B) Histograms from the patients sequencing with indication of found mutations. (C) Localization of mutations within the factor B gene (rectangles represent exons; line represents introns) and within the protein sequence (the 3 domain types—CCP [complement control protein], VWFA [von Willebrand type A], and serine protease are indicated). Numbering is made with the first methionine referred as 1 (as described in Hourcade et al13).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/114/13/10.1182_blood-2009-01-197640/4/zh89990941170001.jpeg?Expires=1724282803&Signature=aoQsg2gN4HV4AexV9LhnIPeV793uEOt9ndL5pT2n~EaB5pcnoscqbfGRl5Ku7zD5s-2znnDBlS69A-9Gu-UxRcaHBAq~H6MNcoYZziuFQl8a8cxIZJQiPg75JXP-0~Ob8~cWyrzOcQR5FY-0obeMfGy3RU3Es2ZsrX~kSCeSFV0IIRtNu48Af-Xc~wU-kPk6kIUc3MhdmYDNsMmxRWY~dB~NBBx73sQlh8W8hjWhg0cQze64A9pcIbT8MqVs9iLhj2ir9FuUvIIGtZfcCN4SrA5twvZradgMp2FkVlAJ87qtU0TNY7wdwKfysxKBo5huheGFlLRGGuliRpeHeM8NOg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Genetic analysis of the described patients. (A) Pedigree of the 2 families. (B) Histograms from the patients sequencing with indication of found mutations. (C) Localization of mutations within the factor B gene (rectangles represent exons; line represents introns) and within the protein sequence (the 3 domain types—CCP [complement control protein], VWFA [von Willebrand type A], and serine protease are indicated). Numbering is made with the first methionine referred as 1 (as described in Hourcade et al13 ).
