CBS9106 inhibits cancer cell growth and CRM1-dependent nuclear export. (A) Structure of CBS9106. (B) Suppression of the cell growth of MM cells by CBS9106. The growth of 2 different MM cells were cultured with indicated doses of CBS9106 for 72 hours and analyzed by the WST-8 method. Growth rate (n = 3) was represented as relative values to those of vehicle-treated control cells. Error bars represent SD. (C) Accumulation of RanBP1 in nucleus by CBS9106 treatment. MM.1S cells were treated with vehicle, LMB (1nM), and CBS9106 (100-800nM) for 2 hours. Fixed cells were stained for RanBP1 (green) and Hoechst (blue) and analyzed by confocal microscopy.