Comparison of prognostic biomarkers and OS by time-dependent AUC for TTFT. (A) Comparison of prognostic biomarkers by time-dependent AUC for TTFT. An AUC of 0.5 signifies no prognostic utility; AUC of 1.0 signifies a perfect predictor. The FLC assay has comparable-to-superior AUC to other CLL prognostic biomarkers. (B) Comparison of prognostic biomarkers for OS by time-dependent AUC.