A core network of ESC-related modules defines expression changes in HT. (A) A core network representing HT was constructed by extracting 19 modules that distinguished DLBCL-t from FL-pt from the full network of 200 modules. Nodes in red indicate modules that are typically up-regulated in DLBCL-T, whereas blue nodes are modules more highly expressed in FL-pt. Stronger coloring and larger size of modules represent the mean fold change in expression between FL-pt and DLBCL-T. White nodes are modules that were not part of the 19-module classifier but are connected to them in the network. Unnumbered modules did not have a significant gene set annotation. Module 9 distinguishes FL-pt from DLBCL-T but is not directly connected to the other core modules in the network. (B) Fold changes for expression of each of the 19 core HT modules were obtained by comparing 12 paired (before and after HT) patient samples in the Glas et al dataset.7 ESC indicates embryonic stem cell signature; HSC, hematopoietic stem cell; and SSS, stromal stem cell.
