Overview of analysis. A module network was constructed from expression data on FL/DLBCL-t⁷  using Genomica. Modules were annotated by comparison with curated gene sets, and a core network, putatively underlying transformation, was identified that involved differentiation/stem cell–related transcriptional programs. We selected modules for incorporation into a survival model using stepwise regression. The survival model was validated in an independent set from a different group.¹¹  Survival analysis based on core modules was performed with and without proliferation genes.