Decreased frequency of iNKT and NK cells, mDCs, and pDCs among PBMCs from HAM/TSP and ATL patients. (A) Representative FACS plot of iNKT cells from HDs, ACs, HAM/TSP patients (HAM), and ATL patients. PBMCs were stained for CD3 and Vα24Jα18, and the expression of CD3 and Vα24Jα18 is plotted. Numbers adjacent to the outlined area indicate the percentage of iNKT cells in total PBMCs. Plots of the frequency of iNKT cells (B), CD56⁺CD16⁺ NK cells (C), mDCs (D), and pDCs (E) among PBMCs from 12 HDs, 12 ACs, 13 HAM/TSP patients, and 11 ATL patients. The horizontal bar represents the mean value for each group. Scheffé F test was used for statistical analysis. Statistically significant differences: *P < .05, **P < .01.