Tissue cystine content in Ctns^−/− mice treated with WT BMCs compared with Ctns^−/− mice treated with Ctns^−/− BMCs. (A) Cystine content at 2 and 4 months in Ctns^−/− mice. Cystine levels increase with time after transplantation of Ctns^−/− BMCs (×). In contrast, cystine content decreases in time after therapy with WT BMCs (▴). (B) Table of percentage decrease in cystine content of Ctns^−/− mice treated with WT BMCs compared with Ctns^−/− mice treated with Ctns^−/− BMCs.