PSTPIP2 negatively regulates STAT1 expression and the activation of Erk1/2 and STAT1 by c-fms in splenic macrophages. (A) CSF-1 and IL-6 signaling in primary SDM from wt and cmo mice. The vertical lines indicate repositioned gel lanes from the same blot. (B) PSTPIP2 overexpression in BAC1.2F5 macrophages inhibits Erk1/2 activation and STAT1 expression. These results were reproduced in 3 to 5 experiments.