Expansion of myeloid progenitors in cmo mice precedes disease onset. (A) Increased frequency of CFU-M in spleens of asymptomatic and diseased cmo mice. (B) Splenic cellularity increases after disease onset. (C) Increased frequency of Mac1⁺ WGA⁺ Ly6C^hi late monocyte precursors in the BM of cmo mice. Data ± SD, n ≥ 3 (A-B), n ≥ 10 (C); *P < .05 versus wt, †P < .05 versus cmo asymptomatic.