The TCR signaling pathway is regulated at multiple levels in CD161^hi CD62L⁺ and CD62L⁻ cells. (A) A transcriptional pathway analysis of the TCR signaling pathway in CD161^hi and CD161^lo CD62L⁺ subsets from 6 healthy donors was created using Ingenuity Systems software (IPA 7). Green and red symbols represent significantly down-regulated or up-regulated genes, respectively, in CD161^hi CD62L⁺ cells compared with their CD161^lo counterparts. White, gray, and orange symbols are not differentially expressed between subsets. (B) Volcano plots showing differentially expressed transcriptional profiles of CD161^hi CD62L⁺ (left) and CD161^hi CD62L⁻ (right) subsets compared with their CD161^lo counterparts are shown from 6 healthy donors. Genes/probes are color-coded as indicated in the legend.