ILT5-specific antibodies can induce cytotoxicity. (A) Complement-mediated cytotoxicity of ILT5-reactive serum (G260/4) and control serum (control) using Bw cells (Bw) or Bw cells expressing ILT5 variant 1 (Bw-ILT5v1). (B) Control Bw cells and Bw cells expressing either ILT5 variant 1 (Bw-ILT5v1) or variant 2 (Bw-ILT5v2) were incubated with interleukin-2–activated lymphocytes in presence of serum G106/1 to test the ability of ILT5-specific antibodies to induce ADCC.