Relationship between MR detection and sampling interval. Correlation between relapse detection frequency and sampling interval (A) as well as median time from MR to HR in days, depending on sampling frequency (B) for RUNX1-RUNX1T1–based MRD follow-up. Full lines (BM) and broken lines (PB) represent sampling interval necessary to achieve 90% relapse detection. The corresponding median times from MR to HR can be seen in panel B.