Atherosclerosis is accelerated in P-sel^ΔCT/ΔCT/apoE^−/− mice compared with P-sel^+/+/apoE^−/−. Animals were maintained on normal chow, and their aortic sinus lesions were evaluated at 16 weeks of age. (A) Quantitative image analysis of aortic sinus lesion area. Male group showed 2.6-fold increased size of the plaque area. Female mice had 1.8-fold larger lesions than control mice. (B) Measurement of percentage of the aortic sinus circumference covered by atherosclerotic plaques. (C) Representative images of Oil Red-O staining of the aortic sinus. Representative images, showing an increase in plaque area in P-sel^ΔCT/ΔCT/apoE^−/− mice compared with P-sel^+/+/apoE^−/− mice (female mice). (D) Quantitative image analysis of macrophage content in the aortic sinus atherosclerotic plaques. Data represent mean ± SEM.