Similar distribution of retroviral integrants relative to proto-oncogenes before and after chemotherapy. Representative gel of RIS amplified by LAM-PCR before (A) and after (B) chemotherapy with either O⁶BG and BCNU (G069 and G154) or O⁶BG and temozolomide (G179 and G197). (C) The positions of RIS mapped relative to the RefSeq gene TSS of proto-oncogenes as defined in either the Sanger Cancer Gene Census or the Retroviral Tagged Cancer Gene Database. *P < .001 (SD).