Survival curves of childhood AML patients with and without WT1 mutations. Kaplan-Meier estimates for 5-year pOS (A) and pEFS (B), showing log-rank P values. The 5-year CIR is depicted in (C) and was analyzed according to the Kalbfleisch and Prentice method using the Gray test for statistical significance. WT1-mutated AML patients have a significantly worse outcome in terms of OS, EFS, and CIR compared with patients with WT1 wild-type AML.