Figure 3
![Figure 3. Clustering of the WT1 gene mutations in the subgroup of childhood CN-AML. WT1 mutations mainly clustered in the CN-AML subgroup. No mutations were found in the CBF-AML subgroup [ie, t(8;21) and inv(16)], and very few were detected in the t(15;17) and in the MLL gene–rearranged childhood AML cases. Mutations were also found in the subgroup with other karyotypes, but at a lower frequency (14.8%) than in the CN-AML subgroup (22.3%).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/113/23/10.1182_blood-2008-09-177949/4/zh80160933530003.jpeg?Expires=1726834875&Signature=F4eLBY3AqdfEK0zHwhurwANui-vkPEnHQMkzt5pIPC9GmYt5nHQG39HBIB91ZdJOGmTlSh-aofNZTzyP0U5YEzdseOLZk9V5Xah80YhKvchqevTCb-BolLDffA-K1VsZxtzY0J-XLq5pLlbVIKsYQildeefy5sAlkP6W4Yy1V9owDzhNN7vxP1Q2YvNx7yuTyIrL-HnzVP5nHsAV7CZCi5DShGq6BNfqIKOUxbrqq5UyWXabWZvyXlvO4Qa09KSRvzV9f4bAabFucKmdsitVBeebkmLcnO6jJBLH6ImSVam9DjteeDGR6XpHlByoXTxKfL9JbOI5I4NHYnN74HM7aQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Clustering of the WT1 gene mutations in the subgroup of childhood CN-AML. WT1 mutations mainly clustered in the CN-AML subgroup. No mutations were found in the CBF-AML subgroup [ie, t(8;21) and inv(16)], and very few were detected in the t(15;17) and in the MLL gene–rearranged childhood AML cases. Mutations were also found in the subgroup with other karyotypes, but at a lower frequency (14.8%) than in the CN-AML subgroup (22.3%).
